Antihyperglycemic activity of verbenone and L-arginine in nicotinamide-streptozotocin-induced diabetic mice: in vitro and in vivo studies

نویسندگان

چکیده

Abstract Background Natural products are utilized globally for the management of diseases such as diabetes mellitus. Carrot seeds ethnobotanically used in This study investigated vitro and vivo antihyperglycemic activities verbenone L-arginine, which compounds found carrot seed. Results Verbenone, their ratios combination expressed significantly α-amylase inhibitory activity with IC 50 13.00, 12.69, 13.30 µg/mL respectively compared acarbose (IC = 12.64 µg/mL) significant α-glucosidases 29.01, 23.76 30.11 16.80 µg/mL). Furthermore, improved glucose uptake yeast cells inhibited haemoglobin glycation vitro. In study, reduced levels blood glucose, liver total cholesterol, triacylglycerol, calculated cardiovascular indices, whereas level plasma high density lipoprotein (HDL) cholesterol was elevated all diabetic treated mice. Conclusion The data revealed antidiabetic L-arginine. Also, ameliorated hyperglycemia, hyperlipidemia other diabetic-induced biochemical alterations NAD-STZ-induced mice model.

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ژورنال

عنوان ژورنال: Beni-Suef University Journal of Basic and Applied Sciences

سال: 2022

ISSN: ['2314-8543', '2314-8535']

DOI: https://doi.org/10.1186/s43088-022-00271-7